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Waardenburg Syndrome: A Rare Pigment Condition

Author: Ellie Wang

Editors: Ken Saito and Peggy Yang

Artists: Serena Yung

Waardenburg syndrome is a rare genetic condition that affects approximately 1 in 42,000 people worldwide. It is categorized into four different types based on the different symptoms and causes, though there are variations in pigmentation of the hair, skin, and eyes. Type I and II are the most common, while Type III and Type IV are rarer. The symptoms of those affected by this syndrome vary widely from person to person, even among immediate family members. Most people inherit the syndrome in an autosomal dominant pattern, which means that only one copy of the mutated gene is needed, instead of two.